dorsal/arxiv
View SchemaEarly bloodmaterial interfacial events and capillary transport on nanoparticle modified nanofibers
| Authors | Romain Scarabelli, Mehdi Abbasi, Magali Gary-Bobo, Christophe Drouet, Marc Leonetti, Ahmed Al-Kattan |
|---|---|
| Categories | |
| ArXiv ID | 2601.05809vv1 |
| URL | https://arxiv.org/abs/2601.05809 |
| License | http://creativecommons.org/licenses/by/4.0/ |
Abstract
Electrospun poly(\epsilon-caprolactone) (PCL)nanofibrous mats are widely considered for blood-contacting wound dressings and small-diameter vascular applications; however, their intrinsic hydrophobicity limits rapid wetting and controlled interaction with blood. In this work, we modulate the interfacial response of PCL nanofibers by incorporating oxide-shelled silicon nanoparticles (SiNPs) synthesized by pulsed laser ablation in liquid, a ligand-free approach that avoids organic stabilizers and preserves surface reactivity. Two composite architectures were designed: SiNPs embedded within the fiber bulk (PAC1,4,16) and SiNPs preferentially exposed at the fiber surface (SPAC1,4,16), with systematically increasing nanoparticle loadings. Structural characterization confirmed the retention of a homogeneous fibrous morphology and the targeted nanoparticle distribution. The dynamic interaction with whole blood was quantified using time-resolved contact-angle measurements, complemented by top-view optical microscopy and three-dimensional profilometry of dried droplets. Pristine PCL remained strongly hydrophobic whereas a hydrophilic PCL functionalized with APTES showed rapid spreading. Incorporation of SiNPs within the fiber volume led to only a moderate enhancement of wettability, and dried droplets retained compact morphologies with limited spreading. In contrast, surface-decorated mats displayed a sharp, concentration-dependent transition toward highly wettable behavior: for SPAC16, the contact angle fell below 20, droplet profiles became markedly flattened, and microscopy revealed extended plasma-rich regions surrounding a red-cell-rich core, indicative of pronounced phase separation within the nanofibrous network.
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"abstract": "Electrospun poly(\\epsilon-caprolactone) (PCL)nanofibrous mats are widely considered for blood-contacting wound dressings and small-diameter vascular applications; however, their intrinsic hydrophobicity limits rapid wetting and controlled interaction with blood. In this work, we modulate the interfacial response of PCL nanofibers by incorporating oxide-shelled silicon nanoparticles (SiNPs) synthesized by pulsed laser ablation in liquid, a ligand-free approach that avoids organic stabilizers and preserves surface reactivity. Two composite architectures were designed: SiNPs embedded within the fiber bulk (PAC1,4,16) and SiNPs preferentially exposed at the fiber surface (SPAC1,4,16), with systematically increasing nanoparticle loadings. Structural characterization confirmed the retention of a homogeneous fibrous morphology and the targeted nanoparticle distribution. The dynamic interaction with whole blood was quantified using time-resolved contact-angle measurements, complemented by top-view optical microscopy and three-dimensional profilometry of dried droplets. Pristine PCL remained strongly hydrophobic whereas a hydrophilic PCL functionalized with APTES showed rapid spreading. Incorporation of SiNPs within the fiber volume led to only a moderate enhancement of wettability, and dried droplets retained compact morphologies with limited spreading. In contrast, surface-decorated mats displayed a sharp, concentration-dependent transition toward highly wettable behavior: for SPAC16, the contact angle fell below 20, droplet profiles became markedly flattened, and microscopy revealed extended plasma-rich regions surrounding a red-cell-rich core, indicative of pronounced phase separation within the nanofibrous network.",
"arxiv_id": "2601.05809",
"authors": [
"Romain Scarabelli",
"Mehdi Abbasi",
"Magali Gary-Bobo",
"Christophe Drouet",
"Marc Leonetti",
"Ahmed Al-Kattan"
],
"categories": [
"cond-mat.soft",
"cond-mat.mtrl-sci"
],
"license": "http://creativecommons.org/licenses/by/4.0/",
"title": "Early bloodmaterial interfacial events and capillary transport on nanoparticle modified nanofibers",
"url": "https://arxiv.org/abs/2601.05809",
"version": "v1"
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